Volume-2 ,Issue-8, August- 2026

Hypothyroidism is a common endocrine disorder that requires lifelong thyroid hormone replacement therapy, regular monitoring, and sustained medication adherence to achieve optimal clinical outcomes. The present case series evaluated the role of clinical pharmacy interventions and patient counselling in the management of four female patients (30–49 years) diagnosed with hypothyroidism. Each case underwent comprehensive prescription review, medication assessment, identification of drug-related problems, and individualized pharmacist-led interventions. Levothyroxine (100 µg once daily) was prescribed in all cases; however, clinically significant issues such as inappropriate medication timing, potential drug–drug interactions involving calcium supplements and proton pump inhibitors, and polypharmacy were identified. Targeted pharmaceutical care included optimization of medication administration, counselling on proper levothyroxine use, adherence reinforcement, and education regarding follow-up monitoring. All patients demonstrated symptomatic improvement following pharmacist intervention, while patients with available laboratory data showed favorable biochemical outcomes, including a reduction in serum thyroid-stimulating hormone (TSH) levels and normalization of thyroid function. This case series highlights the important role of clinical pharmacists in identifying medication-related problems, optimizing pharmacotherapy, improving medication adherence, and enhancing therapeutic outcomes through individualized patient counselling. The findings support the integration of clinical pharmacy services into multidisciplinary management strategies for patients with hypothyroidism.

Keyword: Hypothyroidism, Clinical Pharmacy, Pharmaceutical Care, Patient Counselling, Levothyroxine, Medication Adherence, Drug-Related Problems, Case Series.