Volume-2 ,Issue-6, June- 2026

The present study focused on the formulation and evaluation of sustained release matrix tablets of Selegiline using HPMC K15M as a hydrophilic polymer by the wet granulation method. Pre-formulation studies confirmed the suitability and stability of the drug for sustained release formulation development. Powder blends showed good flowability and compressibility, while all prepared tablets complied with pharmacopoeial limits for physical evaluation parameters such as hardness, friability, weight variation, and thickness. In-vitro drug release studies demonstrated sustained release of Selegiline over 12 hours, with polymer concentration effectively controlling drug release. Among all formulations, F4 showed the most satisfactory sustained release profile comparable to the marketed formulation. Stability studies confirmed that the optimized formulation remained stable under accelerated conditions. Overall, the study concluded that Selegiline sustained release matrix tablets can be successfully developed using HPMC to achieve prolonged drug release and improved therapeutic efficacy in Parkinson’s disease management.

Keyword: Selegiline; Sustained Release Matrix Tablets; HPMC K15M; Wet Granulation; Controlled Drug Release; Parkinson’s Disease.