Volume-2 ,Issue-6, June- 2026

The present study focused on the formulation and evaluation of a stable oral suspension of spironolactone to improve its dispersion, uniformity, and patient acceptability. Preformulation studies confirmed the drug’s identity, purity, poor aqueous solubility, and lipophilic nature. Different formulations (F1–F10) were prepared using suitable suspending and wetting agents and evaluated for micromeritic properties, pH, viscosity, sedimentation volume, particle size, drug content, and in vitro drug release. Among all batches, formulation F10 showed the best performance with excellent homogeneity, optimum viscosity, high sedimentation volume, uniform drug content, and maximum drug release. Stability studies under ICH conditions demonstrated that the optimized formulation remained physically and chemically stable throughout the study period. Overall, the study confirmed that the developed spironolactone oral suspension is stable, effective, and suitable for further pharmaceutical development.

Keyword: Spironolactone, Oral suspension, Preformulation studies, Micromeritic properties, Drug release, Stability studies