Volume-2 ,Issue-6, June- 2026

The present study aimed to develop and evaluate a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of the antimalarial drug Pyronaridine to enhance its solubility, dissolution rate, and oral bioavailability. Due to its poor aqueous solubility, Pyronaridine was formulated into a lipid-based SNEDDS using suitable oils, surfactants, and co-surfactants, which showed rapid self-emulsification and stable nanoemulsion formation. The optimized liquid formulation was converted into a solid form using adsorption onto colloidal silicon dioxide and further compressed into tablets. The developed S-SNEDDS was evaluated for physicochemical properties, including flow characteristics, drug content, droplet size, polydispersity index, zeta potential, encapsulation efficiency, and in vitro drug release. Among all formulations, F10 exhibited the best performance with nanosized droplets, high stability, and nearly complete drug release within 60 minutes. Stability studies confirmed that the formulation remained stable under both long-term and accelerated conditions. Overall, the study demonstrates that S-SNEDDS is an effective approach to improve the biopharmaceutical performance of Pyronaridine and may enhance its therapeutic efficacy in antimalarial treatment.

Keyword: Pyronaridine, solid self-nanoemulsifying drug delivery system (S-SNEDDS), SNEDDS, nanoemulsion, lipid-based drug delivery, solubility enhancement