Volume-2 ,Issue-6, June- 2026

The present study aimed to develop and characterize lurasidone-loaded niosomes to improve oral bioavailability and targeted brain delivery. Lurasidone-loaded niosomes were prepared by the thin film hydration method using Span surfactants and cholesterol. Preformulation studies confirmed the poor aqueous solubility and lipophilic nature of lurasidone, supporting the need for a vesicular delivery system. The prepared formulations were evaluated for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, drug content, in-vitro drug release, and stability. Among all formulations, F10 showed optimized characteristics with nanosized vesicles, high entrapment efficiency, good stability, and sustained drug release over 24 hours. Stability studies performed according to ICH guidelines demonstrated minimal changes in formulation parameters during storage. The study concluded that lurasidone-loaded niosomes are a promising approach for enhancing solubility, bioavailability, and brain-targeted delivery of lurasidone.

Keyword: Lurasidone, Niosomes, Thin Film Hydration Method, Oral Bioavailability, Brain Targeting, Nanovesicular Drug Delivery