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Ocimum sanctum Linn. (Tulsi) is a well-established medicinal herb renowned for its diverse pharmacological activities, including antioxidant, anti-inflammatory, adaptogenic, and neuroprotective effects. However, its therapeutic potential is often limited by poor aqueous solubility and bioavailability of key phytoconstituents. The present study aimed to develop and evaluate self-nanoemulsifying tablet formulations of Ocimum sanctum extract to enhance its dissolution rate, stability, and overall pharmacological efficacy. Various tablet formulations were prepared using a combination of surfactants (Tween 80), co-solvents (polyvinylpyrrolidone), and oils (corn oil), and evaluated for physical parameters such as weight variation, hardness, friability, and thickness. The optimized formulation demonstrated acceptable pharmaceutical properties with improved disintegration time and enhanced dissolution profile. Phytochemical screening confirmed the presence of bioactive compounds including flavonoids, alkaloids, glycosides, and saponins. Additionally, behavioral studies such as the open field test suggested potential anxiolytic activity of the formulated tablets. These findings support the feasibility of using SNEDDS technology to improve the therapeutic performance of herbal extracts like Ocimum sanctum in a stable and patient-friendly dosage form.

Keyword: Ocimum sanctum, Tulsi, Self-Nanoemulsifying Drug Delivery System (SNEDDS), Herbal Tablets, Phytochemical Screening.