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The present study focuses on the formulation and evaluation of Glibenclamide-loaded nanoparticle tablets intended for sustained antidiabetic therapy. Nanoparticles were prepared using a chitosan-based system and optimized for various physicochemical parameters including particle size, zeta potential, drug loading, and swelling index. The drug-loaded nanoparticles were compressed into tablets and evaluated for weight variation, hardness, friability, disintegration time, and in vitro drug release. Among the formulations, NT-10 exhibited a high swelling index (2.887) and sustained release behavior up to 96.27% over 24 hours, indicating its potential for prolonged blood glucose control. Stability studies conducted under accelerated conditions showed no significant changes in physical appearance or drug content, affirming the robustness of the formulation. This nanoparticulate system enhances the solubility and bioavailability of Glibenclamide, offering a promising platform for sustained drug delivery in diabetes management.

Keyword: Glibenclamide, nanoparticles, sustained release, chitosan, drug loading