Current Issues

The present study focuses on the formulation and evaluation of a topical herbal gel containing methanolic extracts of Cassia fistula fruit pulp and Lawsonia inermis leaves, both known for their traditional use in treating inflammatory conditions. Preliminary phytochemical screening revealed the presence of flavonoids, alkaloids, glycosides, tannins, and saponins, which are associated with anti-inflammatory activity. Ten gel formulations (FM1–FM10) were developed using varying concentrations of gelling agents such as Carbopol 940 and HPMC. The formulations were evaluated for physicochemical parameters including pH, spreadability, viscosity, homogeneity, and extrudability. In vitro anti-inflammatory activity was assessed by the albumin denaturation assay, where FM-7 and FM-8 showed significant inhibition comparable to the standard drug diclofenac. In vitro drug release studies confirmed a sustained release profile, especially in FM-8, indicating effective topical delivery. The results demonstrate that the combination of Cassia fistula and Lawsonia inermis in gel form offers a promising and natural alternative for topical anti-inflammatory therapy.

Keyword: Cassia fistula, Lawsonia inermis, herbal gel, anti-inflammatory activity, phytochemical screening.